ten ofovir-maleate

By Targets:	TET Protein (2) 5-HT Receptor (1) Apoptosis (1) Drug Metabolite (2) Endogenous Metabolite (3) Epigenetic Reader Domain (2) Estrogen Receptor/ERR (2) JAK (1) Ligands for Target Protein for PROTAC (2) PKC (2) Potassium Channel (1) PROTACs (1) Proteasome (1) Ras (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (1) STAT (1)
By Research Areas:	Cancer (10) Infection (1) Neurological Disease (2)

Targets Recommended: TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117286

(S)-JQ-35 ten-010	Epigenetic Reader Domain	Cancer
(S)-JQ-35 (TEN-010) is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.

HY-W012570

Decyl aldehyde

Endogenous Metabolite Infection

Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate.
HY-139649

Ten01

JAK Others

Ten01 has 5.0 nM activity against JAK1 kinase.

Decyl aldehyde	Endogenous Metabolite	Infection
Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate.

Ten01	JAK	Others
Ten01 has 5.0 nM activity against JAK1 kinase.

HY-RS14361

TEN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TEN1 Human Pre-designed siRNA Set A contains three designed siRNAs for TEN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TEN1 Human Pre-designed siRNA Set A TEN1 Human Pre-designed siRNA Set A

HY-N5041

9'''-Methyl salvianolate B

Others Others

9'''-Methyl salvianolate B is a methanolic extract of Cynoglossum columnae Ten. plants .

9'''-Methyl salvianolate B	Others	Others
9'''-Methyl salvianolate B is a methanolic extract of Cynoglossum columnae Ten. plants .

HY-122258

NSC-370284	STAT TET Protein	Cancer
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 .

HY-130988A

Ipatasertib-NH2 dihydrochloride GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride	Ligands for Target Protein for PROTAC	Cancer
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase .

HY-129099

N-Desmethyltamoxifen	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite	Cancer
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-129099A

N-Desmethyltamoxifen hydrochloride	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite	Cancer
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-136563

RA375	Proteasome Apoptosis Reactive Oxygen Species	Cancer
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead .

HY-W396714

Succinic acid sodium Wormwood acid sodium	Potassium Channel TET Protein	Neurological Disease
Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten‑eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research .

HY-130988

Ipatasertib-NH2 GDC-0068-NH2; RG7440-NH2	Ligands for Target Protein for PROTAC	Cancer
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase .

HY-126247

BI-2852	Ras	Cancer
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

HY-129937A

GNE-987	PROTACs Epigenetic Reader Domain	Cancer
GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC₅₀=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC₅₀=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC) .

HY-126247B

(R)-BI-2852	Others	Cancer
(R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

HY-103120

Org37684	5-HT Receptor	Neurological Disease
Org37684 is a highly potent 5-HT_2C receptor agonist (pEC₅₀=8.17). Org37684 exhibits a rank order of potency of 5-HT_2C>5-HT_2B>5-HT_2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC₅₀=7.96) and ten times for the 5-HT_2A (pEC₅₀=7.11) receptor .

Cat. No.	Product Name	Target	Research Area

HY-P5173

MitTx-beta	Peptides	Others
MitTx-beta is a peptide can be isolated from the venom of the Texas coral snake (Micrurus tener tener). MitTx-beta can form a complex with MitTx-α, MitTx. MitTx has ASIC1 channel activating activity on capsaicin-sensitive nerve fibers .

HY-P5954

PLTX-II	Peptides	Others
PLTX-II is a calcium channel blocker. PLTX-II has a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012570

Decyl aldehyde	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate.

HY-129099A

N-Desmethyltamoxifen hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-N5041

9'''-Methyl salvianolate B	Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Other Diseases Phenols Polyphenols Plants Disease Research Fields	Others
9'''-Methyl salvianolate B is a methanolic extract of Cynoglossum columnae Ten. plants .

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

Species:	Human (2)
Tag:	His (2) Myc (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71448

	ITGBL1 Protein, Human (Myc, His) ITGBL1; OSCP; TIED; Integrin beta-like protein 1; Osteoblast-specific cysteine-rich protein; ten integrin EGF-like repeat domain-containing protein	Human	E. coli
	Integrin beta-like protein 1 (ITGBL1) is a beta integrin-related protein that is a member of the EGF-like protein family, containing integrin-like cysteine-rich repeats and may has integrin binding activity. ITGBL1 might be involved in cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. ITGBL1 Protein, Human (Myc, His) is the recombinant human-derived ITGBL1 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of ITGBL1 Protein, Human (Myc, His) is 471 a.a., with molecular weight of ~67 kDa.

HY-P701072

	TENM2 Protein, Human (HEK293, His) teneurin-2; ten-2; tenascin-M2; ten-m2; KIAA1127; ODZ2; TNM2	Human	HEK293
	TENM2 Protein plays a crucial role in neural development, facilitating proper connectivity in the nervous system by promoting filopodia formation and enlarged growth cones in neurons. It functions as a ligand for the ADGRL1 receptor, mediating axon guidance and heterophilic cell-cell adhesion. TENM2 Protein, Human (HEK293, His) is the recombinant human-derived TENM2 protein, expressed by HEK293 , with N-His labeled tag. The total length of TENM2 Protein, Human (HEK293, His) is 441 a.a., with molecular weight of 53-63 kDa.


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ten ofovir-maleate

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